In Vivo Core Team Leader, Cardiovascular & Metabolic Disease

29 Jul 2017
26 Aug 2017
Contract Type
Full Time

Location - Cambridge, UK

Permanent role; Senior Scientist/Principal Scientist level

If you're inspired by the possibilities of science to change lives and you thrive when making brave decisions - join us.

MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you'll have the opportunity to make a difference in people's lives every day. As one of the world's premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.

As the Team Leader of the In Vivo Core Team within the Cardiovascular and Metabolic Disease (CVMD) group at Cambridge, UK you will report to the Director of CVMD research in Cambridge and play a key role in managing the delivery of in vivo pharmacology studies required to progress drug projects for metabolic disease and its complications.

MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Main Duties and Responsibilities

MedImmune is committed to growing its Cardiovascular & Metabolic Disease (CVMD) Research & Development capability and the successful candidate will enable the progression of an expanding drug project portfolio in diabetes, obesity and diabetic complications.

Using your technical, practical and scientific experience of physiology and pharmacology in the use of animal models in drug discovery, as well as your accomplished leadership and management skills in a pharmaceutical industry setting, you will be accountable for the progression of CVMD projects. This role requires both an element of "hands-on" laboratory based work as well as line management experience. You will be expected to demonstrate scientific leadership and remain active in the laboratory and work flexibly across different drug discovery project teams.

Key responsibilities include:

  • Lead a team of in vivo pharmacologists to deliver efficacy and PK data to projects.
  • Work closely with CVMD colleagues in Gaithersburg, MD to deliver data across sites.
  • Be the Home Office Project Licence Holder for CVMD research, accountable for the experimental work of the group under the authority of the licence.
  • Conduct regulated experimental procedures requiring compliance with the Home Office Animal (Scientific Procedures) Act 1986 and EU Directive 2010/63.
  • Lead the interactions and delivery of in vivo data through contract research organisations and/or collaborations.
  • Design and deliver the in vivo efficacy, PKPD and mechanism of action studies for biologics drug leads/candidates in animal models of metabolic disease and its complications.
  • Take a leading role in in-vivo and ex-vivo experimental work including collection, analysis and interpretation of accurate scientific data and represent the in vivo core team at drug project meetings and governance committees.
  • Act as in vivo lead on drug project teams, setting in vivo strategies for the project.
  • Contribute to rodent animal model development and characterisation embracing novel technologies in the following areas: obesity, diabetes, dyslipidaemia, cardiovascular disease, NASH and renal disease.
  • Critically evaluate and interpret in vivo efficacy, PKPD and mechanism of action of novel therapeutics.
  • Appreciate and understand the translational benefits of animal disease models.

Essential Requirements

  • A MD/PhD/DVM in a relevant field with post-doctoral experience preferably with industry research experience or a BSc with considerable in vivo experience in an industry setting
  • Experience with line managing a team of in vivo scientists
  • Experience holding and managing a Home Office Project Licence.
  • Practical hands-on experience in the in-vivo laboratory of a pharmaceutical, biotechnology or academic environment.
  • Experience leading in vivo efficacy, PKPD and mechanism of action studies in a drug discovery setting.
  • Evidence of scientific contribution to the field of metabolic disease research through publications and or presentations.
  • Evidence of independent analysis of tissue, blood and urine samples using biological and molecular biology assays.

Desirable Requirements

  • Experience of working with models of obesity, diabetes, dyslipidaemia, cardiovascular disease, NASH or renal disease
  • Significant experience in pharmaceutical drug discovery research setting

Next Steps - Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

MedImmune is an equal opportunity employer. MedImmune will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Closing date for applications: 28th August 2017

Competitive remuneration and company benefits apply.