Neuroscience Discovery Safety Lead

5 days left

AstraZeneca - Cambridge
01 Aug 2017
29 Aug 2017
Contract Type
Full Time

Neuroscience Discovery Safety Lead

Location: Cambridge, UK

Salary: Competitive & Excellent Benefits Package

At AstraZeneca we win through science, it's at the heart of our every success. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.

As a Neuroscience Discovery Safety Lead within Discovery Safety you will play a pivotal role in overcoming major challenges in the discovery of innovative medicines: ensuring they are safe enough to provide novel treatments for patients. In Discovery Safety, a global department that is part of our Drug Safety and Metabolism function, we apply innovative science to drive the design and selection of safer medicines. As true Drug Hunting partners to our Innovative Medicines units, we contribute to the selection of novel drug targets, design of therapeutic concepts, identification and optimization of new chemical series as well as a range of other modalities, and selection of novel candidate drugs. We develop and apply cutting edge in silico, molecular, cellular and in vivo technologies and push the boundaries of predictive safety science with our mission in mind: driving our science to bring better, safer medicines to patients sooner.

In Drug Safety and Metabolism, we place a strong emphasis on talent development. You will be able to develop your scientific leadership by working together with leaders in neuroscience, investigative toxicology, drug discovery, cell biology and predictive safety science.

Bring your scientific excellence in Neuroscience to Discovery Safety and become a key player in the discovery of innovative medicines.

Main Duties and Responsibilities

As a Neuroscience Discovery Safety Lead you will be working closely with neuroscience colleagues and through the application of in-depth neurobiology, develop a strong understanding of target related safety risks for both small and large molecule neuroscience and pain opportunities within AZ IMED. You will design and execute experimental strategies to predict, assess and mitigate target- and drug-related safety risks, and drive the development of molecular and cellular mechanistic understanding of safety aspects for neuroscience projects.

You will be accountable for the delivery of the safety strategy for Neuroscience discovery projects, and be an integral member of discovery project teams, ensuring the delivery of experimental data that will impact project decision making with the aim to develop molecules with the "Right Safety" profile.

Essential Requirements

  • A PhD in a neuroscience, or toxicology/pharmacology related field with experience of application to neuroscience, and evidence of a strong scientific track record and problem-solving capabilities.
  • Highly motivated, creative, innovative, reliable scientist, with a flexible and collaborative team-oriented mind-set, who solves problems in a goal-focused fashion and is keen to create impact.
  • The ability to build an understanding of biology around novel targets and pathways, develop testable hypotheses, and drive scientific learning.
  • Experience in experimental design, generation and interpretation of high quality experimental data and translating scientific findings.
  • Excellent communication and presentation skills and the ability to work across multi-disciplinary teams.
  • A social personality that contributes to an open, positive, collaborative working climate, and a strong desire to drive personal development.

Desired Requirements

  • Appreciation and understanding of techniques and technologies relevant to in vitro systems, including cell culture and cell-based assay systems utilising cell lines and primary cells (examples could include high content screening, -omics technologies, advanced cell systems, gene editing, microphysiological systems).
  • Understanding of the drug discovery process from experience in the biotech/pharmaceutical industry.
  • Experience with design and execution of in-vitro and in-vivo experiments to determine the effects of therapeutics on biological systems, including data analysis.
  • Knowledge of predictive toxicology, safety and risk assessment.

If you are interested, apply now!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

Opening date: 31st July 2017

Closing date: 30th August 2017