Scientific Leader, Lung Repair and Regeneration
Location: Cambridge; Permanent
If you're inspired by the possibilities of science to change lives and you thrive when making brave decisions - join us.
MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you'll have the opportunity to make a difference in people's lives every day. As one of the world's premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.
We are seeking a highly motivated Lung Repair and Regeneration Senior Scientist with a broad understanding of the pathophysiological mechanisms underlying respiratory diseases such as chronic obstructive pulmonary disease, asthma and idiopathic pulmonary fibrosis, particularly those driving tissue damage, remodelling and repair. As a member of the Respiratory, Autoimmunity and Inflammation (RIA) research group in Cambridge UK, you will work as part of a team discovering and developing novel therapeutics for the treatment of inflammatory diseases with a focus on respiratory diseases.
MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.
Main Duties and Responsibilities
In this role, you will work as part of a preclinical team focused on expanding our portfolio of biologics drug projects for the treatment of respiratory, inflammatory and autoimmune diseases. You will be expected to demonstrate an exceptionally high level of enthusiasm for innovative scientific research leading to the discovery and development of novel therapeutics. You will use your extensive expertise in tissue regeneration and repair, epithelial cell biology, stem cell biology, and/or complex co-culture systems, and will apply it to your understanding of the basic mechanisms of human lung disease, to develop novel therapeutics.
You will be responsible for driving target validation and drug projects through novel biological discovery. You will also develop and lead novel technical advances with human tissue such as complex 3D co-culture systems, imaging or similar, relevant to lung repair and regeneration . As part of your role you will be encouraged to collaborate with scientists from a variety of functional teams in Cambridge and with our site in Gaithersburg, USA. There is also the potential of having responsibility for 1-2 junior team members, for which you will need to be able to demonstrate a clear developing ability to mentor/inspire, develop and collaborate well with others.
- PhD with post-doctoral experience in academia or industry.
- The ability to develop in vitro and ex-vivo models to understand mechanisms important in establishing epithelial repair/regeneration and/or stromal and immune cell interactions with epithelium in lung.
- OR a strong understanding of lung developmental biology which can be applied to novel target discovery in disease.
- Scientific creativity and ability to drive own research ideas to a successful conclusion, demonstrated by strong publication record or project progression.
- Strong understanding of translation of mechanistic findings to human disease.
- Experience of in vivo models of lung damage, chronic inflammation or infection of lung.
- Understanding of stem cell biology.
- Understanding of other organ epithelial repair biology, such as intestinal epithelium.
- A background in human translational approaches and basic understanding of biological mechanisms in disease.
- Entry-level leadership potential demonstrated.
- Excellent written, oral, presentation and inter-personal skills.
- Ability to motivate and encourage others.
- Successful team working and collaboration skills.
Next Steps - Apply Today!
To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.
MedImmune is an equal opportunity employer. MedImmune will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.
Closing date for applications - 1st Sept 2017
Competitive remuneration and company benefits apply